Pathway analysis of bladder cancer genome-wide association study identifies novel pathways involved in bladder cancer development.

ABSTRACT: Genome-wide association studies (GWAS) are designed to identify individual regions associated with cancer risk, but only explain a small fraction of the inherited variability. Alternative approach analyzing genetic variants within biological pathways has been proposed to discover networks of susceptibility genes with additional effects. The gene set enrichment analysis (GSEA) may complement and expand traditional GWAS analysis to identify novel genes and pathways associated with bladder cancer risk. We selected three GSEA methods: Gen-Gen, Aligator, and the SNP Ratio Test to evaluate cellular signaling pathways involved in bladder cancer susceptibility in a Texas GWAS population. The candidate genetic polymorphisms from the significant pathway selected by GSEA were validated in an independ

SUBMITTER: Chen M 

PROVIDER: S-EPMC5059113 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature