ADAM17 in tumor associated leukocytes regulates inflammatory mediators and promotes mammary tumor formation.

ABSTRACT: The presence of inflammatory cells within the tumor microenvironment has been tightly linked to mammary tumor formation and progression. Specifically, interactions between tumor cells and infiltrating macrophages can contribute to the generation of a pro-tumorigenic microenvironment. Understanding the complex mechanisms that drive tumor cell-macrophage cross-talk will ultimately lead to the development of approaches to prevent or treat early stage breast cancers. As described here, we demonstrate that the cell surface protease a disintegrin and metalloproteinase 17 (ADAM17) is expressed by macrophages in mammary tumors and contributes to regulating the expression of pro-inflammatory mediators, including inflammatory cytokines and the inflammatory mediator cyclooxygenase-2 (Cox-2). Furtherm

SUBMITTER: Bohrer LR 

PROVIDER: S-EPMC5059114 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature