Ontology highlight
ABSTRACT:
SUBMITTER: Perol L
PROVIDER: S-EPMC5059699 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Pérol Louis L Lindner John M JM Caudana Pamela P Nunez Nicolas Gonzalo NG Baeyens Audrey A Valle Andrea A Sedlik Christine C Loirat Delphine D Boyer Olivier O Créange Alain A Cohen José Laurent JL Rogner Ute Christine UC Yamanouchi Jun J Marchant Martine M Leber Xavier Charles XC Scharenberg Meike M Gagnerault Marie-Claude MC Mallone Roberto R Battaglia Manuela M Santamaria Pere P Hartemann Agnès A Traggiai Elisabetta E Piaggio Eliane E
Nature communications 20161006
Type 1 diabetes (T1D) is characterized by a chronic, progressive autoimmune attack against pancreas-specific antigens, effecting the destruction of insulin-producing β-cells. Here we show interleukin-2 (IL-2) is a non-pancreatic autoimmune target in T1D. Anti-IL-2 autoantibodies, as well as T cells specific for a single orthologous epitope of IL-2, are present in the peripheral blood of non-obese diabetic (NOD) mice and patients with T1D. In NOD mice, the generation of anti-IL-2 autoantibodies i ...[more]