Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.

ABSTRACT: DNA N⁶-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ?0.1-0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.

SUBMITTER: Liu J 

PROVIDER: S-EPMC5059759 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature