Striatal prediction errors support dynamic control of declarative memory decisions.

ABSTRACT: Adaptive memory requires context-dependent control over how information is retrieved, evaluated and used to guide action, yet the signals that drive adjustments to memory decisions remain unknown. Here we show that prediction errors (PEs) coded by the striatum support control over memory decisions. Human participants completed a recognition memory test that incorporated biased feedback to influence participants' recognition criterion. Using model-based fMRI, we find that PEs-the deviation between the outcome and expected value of a memory decision-correlate with striatal activity and predict individuals' final criterion. Importantly, the striatal PEs are scaled relative to memory strength rather than the expected trial outcome. Follow-up experiments show that the learned recognition criter

SUBMITTER: Scimeca JM 

PROVIDER: S-EPMC5059768 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature