MiR-150 exerts antileukemia activity in vitro and in vivo through regulating genes in multiple pathways.

ABSTRACT: MicroRNAs, a class of small noncoding RNAs, have been implicated to regulate gene expression in virtually all important biological processes. Although accumulating evidence demonstrates that miR-150, an important regulator in hematopoiesis, is deregulated in various types of hematopoietic malignancies, the precise mechanisms of miR-150 action are largely unknown. In this study, we found that miR-150 is downregulated in samples from patients with acute lymphoblastic leukemia, acute myeloid leukemia, and chronic myeloid leukemia, and normalized after patients achieved complete remission. Restoration of miR-150 markedly inhibited growth and induced apoptosis of leukemia cells, and reduced tumorigenicity in a xenograft leukemia murine model. Microarray analysis identified multiple novel target

SUBMITTER: Fang ZH 

PROVIDER: S-EPMC5059860 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature