Distal regulation of c-myb expression during IL-6-induced differentiation in murine myeloid progenitor M1 cells.

ABSTRACT: The c-Myb transcription factor is a major regulator that controls differentiation and proliferation of hematopoietic progenitor cells, which is frequently deregulated in hematological diseases, such as lymphoma and leukemia. Understanding of the mechanisms regulating the transcription of c-myb gene is challenging as it lacks a typical promoter and multiple factors are involved. Our previous studies identified some distal regulatory elements in the upstream regions of c-myb gene in murine myeloid progenitor M1 cells, but the detailed mechanisms still remain unclear. In the present study, we found that a cell differentiation-related DNase1 hypersensitive site is located at a -28k region upstream of c-myb gene and that transcription factors Hoxa9, Meis1 and PU.1 bind to the -28k region. Circu

SUBMITTER: Zhang J 

PROVIDER: S-EPMC5059869 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature