Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress response.

ABSTRACT: Arginyltransferase 1 (Ate1) mediates protein arginylation, a poorly understood protein posttranslational modification (PTM) in eukaryotic cells. Previous evidence suggest a potential involvement of arginylation in stress response and this PTM was traditionally considered anti-apoptotic based on the studies of individual substrates. However, here we found that arginylation promotes cell death and/or growth arrest, depending on the nature and intensity of the stressing factor. Specifically, in yeast, mouse and human cells, deletion or downregulation of the ATE1 gene disrupts typical stress responses by bypassing growth arrest and suppressing cell death events in the presence of disease-related stressing factors, including oxidative, heat, and osmotic stresses, as well as the exposure to heav

SUBMITTER: Kumar A 

PROVIDER: S-EPMC5059882 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature