Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.

ABSTRACT:

Objectives

Chronic hypertension is the most critical risk factor for cardiovascular disease, heart failure, and stroke.

Approach and results

Here we show that wild-type mice infused with angiotensin II develop hypertension, cardiac hypertrophy, perivascular fibrosis, and endothelial dysfunction with enhanced stromal interaction molecule 1 (STIM1) expression in heart and vessels. All these pathologies were significantly blunted in mice lacking STIM1 specifically in smooth muscle (Stim1(SMC-/-)). Mechanistically, STIM1 upregulation during angiotensin II-induced hypertension was associated with enhanced endoplasmic reticulum stress, and smooth muscle STIM1 was required for endoplasmic reticulum stress-induced vascular dysfunction through transforming growth factor-β and nicotin

SUBMITTER: Kassan M 

PROVIDER: S-EPMC5061131 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature