Digitized Spiral Drawing: A Possible Biomarker for Early Parkinson's Disease.

ABSTRACT:

Introduction

Pre-clinical markers of Parkinson's Disease (PD) are needed, and to be relevant in pre-clinical disease, they should be quantifiably abnormal in early disease as well. Handwriting is impaired early in PD and can be evaluated using computerized analysis of drawn spirals, capturing kinematic, dynamic, and spatial abnormalities and calculating indices that quantify motor performance and disability. Digitized spiral drawing correlates with motor scores and may be more sensitive in detecting early changes than subjective ratings. However, whether changes in spiral drawing are abnormal compared with controls and whether changes are detected in early PD are unknown.

Methods

138 PD subjects (50 with early PD) and 150 controls drew spirals on a digitizing tablet, generat

SUBMITTER: San Luciano M 

PROVIDER: S-EPMC5061372 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature