Ontology highlight
ABSTRACT:
SUBMITTER: Quiliano M
PROVIDER: S-EPMC5061469 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
International journal for parasitology. Drugs and drug resistance 20160928 3
Synthesis of new 1-aryl-3-substituted propanol derivatives followed by structure-activity relationship, in silico drug-likeness, cytotoxicity, genotoxicity, in silico metabolism, in silico pharmacophore modeling, and in vivo studies led to the identification of compounds 22 and 23 with significant in vitro antiplasmodial activity against drug sensitive (D6 IC<sub>50</sub> ≤ 0.19 μM) and multidrug resistant (FCR-3 IC<sub>50</sub> ≤ 0.40 μM and C235 IC<sub>50</sub> ≤ 0.28 μM) strains of Plasmodium ...[more]