Inflammation induced by inhaled lipopolysaccharide depends on particle size in healthy volunteers.

ABSTRACT:

Aims

In drug development, the anti-inflammatory properties of new molecules in the lung are currently tested using the inhaled lipopolysaccharide (LPS) model. The total and regional lung bioavailability of inhaled particles depends significantly on their size. The objective of the present study was to compare inflammatory responses in healthy volunteers after the inhalation of LPS of varying droplet size.

Methods

Three nebulizers were characterized by different droplet size distributions [mean mass median aerodynamic diameters: Microcirrus (2.0 μm), MB2 (3.2 μm) and Pari (7.9 μm)]. Participants inhaled three boluses of a 20 μg (technetium 99 m-labelled) solution of LPS, randomly delivered by each nebulizer. We measured the lung deposition of the nebulized LPS by gamma-scinti

SUBMITTER: Doyen V 

PROVIDER: S-EPMC5061781 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature