ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress.

ABSTRACT: Chronic exposure to stressful environment is a key risk factor contributing to the development of depression. However, the mechanisms involved in this process are still unclear. Brain-derived neurotropic factor (BDNF) has long been investigated for its positive role in regulation of mood, although the role of its precursor, proBDNF, in regulation of mood is not known. In this study, using an unpredictable chronic mild stress (UCMS) paradigm we found that the protein levels of proBDNF were increased in the neocortex and hippocampus of stressed mice and this UCMS-induced upregulation of proBDNF was abolished by chronic administration of fluoxetine. We then established a rat model of UCMS and found that the expression of proBDNF/p75^NTR/sortilin was upregulated, whereas the expressi

SUBMITTER: Bai YY 

PROVIDER: S-EPMC5061880 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature