A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors.

ABSTRACT: The effects of serotonin (5-HT) on anxiety and depression are mediated by a number of 5-HT receptors, including autoreceptors that act to inhibit 5-HT release. While the majority of anxiety and depression-related research has focused on the 5-HT_1A receptor, the 5-HT_1B receptor has a lesser known role in modulating emotional behavior. 5-HT_1B receptors are inhibitory GPCRs located on the presynaptic terminal of both serotonin and non-serotonin neurons, where they act to inhibit neurotransmitter release. The autoreceptor population located on the axon terminals of 5-HT neurons is a difficult population to study due to their diffuse localization throughout the brain that overlaps with 5-HT_1B heteroreceptors (receptors located on non-serotonergic neur

SUBMITTER: Nautiyal KM 

PROVIDER: S-EPMC5061886 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature