Deep Brain Stimulation in Animal Models of Fear, Anxiety, and Posttraumatic Stress Disorder.

ABSTRACT: Although medications and psychotherapy are often effective for the treatment of posttraumatic stress disorder (PTSD), 20-30% of patients do not respond to these conventional therapies. In psychiatry, DBS has been either approved or is currently under investigation for different disorders. At present, whether DBS may be used to treat PTSD remains unknown. Preclinical research may provide the scientific rationale for helping conceive and further improve such trials. Some of the animal models commonly used to date are more suitable for investigating mechanisms of anxiety and fear than the long-lasting behavior that characterized PTSD. That said, mechanisms and neurocircuits involved in paradigms such as fear conditioning and extinction share several common features with those of PTSD. In this

SUBMITTER: Reznikov R 

PROVIDER: S-EPMC5061888 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature