Gene expression profiling identifies distinct molecular subgroups of leiomyosarcoma with clinical relevance.

ABSTRACT:

Background

Soft tissue sarcomas are heterogeneous and a major complication in their management is that the existing classification scheme is not definitive and is still evolving. Leiomyosarcomas, a major histologic category of soft tissue sarcomas, are malignant tumours displaying smooth muscle differentiation. Although defined as a single group, they exhibit a wide range of clinical behaviour. We aimed to carry out molecular classification to identify new molecular subgroups with clinical relevance.

Methods

We used gene expression profiling on 20 extra-uterine leiomyosarcomas and cross-study analyses for molecular classification of leiomyosarcomas. Clinical significance of the subgroupings was investigated.

Results

We have identified two distinct molecular subgroups

SUBMITTER: Lee YF 

PROVIDER: S-EPMC5061910 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature