Feeling, learning from and being aware of inner states: interoceptive dimensions in neurodegeneration and stroke.

ABSTRACT: Interoception is a complex process encompassing multiple dimensions, such as accuracy, learning and awareness. Here, we examined whether each of those dimensions relies on specialized neural regions distributed throughout the vast interoceptive network. To this end, we obtained relevant measures of cardiac interoception in healthy subjects and patients offering contrastive lesion models of neurodegeneration and focal brain damage: behavioural variant fronto-temporal dementia (bvFTD), Alzheimer's disease (AD) and fronto-insular stroke. Neural correlates of the three dimensions were examined through structural and functional resting-state imaging, and online measurements of the heart-evoked potential (HEP). The three patient groups presented deficits in interoceptive accuracy, associated wit

SUBMITTER: Garcia-Cordero I 

PROVIDER: S-EPMC5062096 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature