Identification of a common mesenchymal stromal progenitor for the adult haematopoietic niche.

ABSTRACT: Microenvironment cues received by haematopoietic stem cells (HSC) are important in regulating the choice between self-renewal and differentiation. On the basis of the differential expression of cell-surface markers, here we identify a mesenchymal stromal progenitor hierarchy, where CD45^-Ter119^-CD31^-CD166^-CD146^-Sca1⁺(Sca1⁺) progenitors give rise to CD45^-Ter119^-CD31^-CD166^-CD146⁺(CD146⁺) intermediate and CD45^-Ter119^-CD31^-CD166⁺CD146^-(CD166⁺) mature osteo-progenitors. All three progenitors preserve HSC long-term multi-lineage reconstitution capability in vitro; however, their in vivo fate

SUBMITTER: Hu X 

PROVIDER: S-EPMC5062560 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature