Partial restoration of the microbiota of cesarean-born infants via vaginal microbial transfer.

ABSTRACT: Exposure of newborns to the maternal vaginal microbiota is interrupted with cesarean birthing. Babies delivered by cesarean section (C-section) acquire a microbiota that differs from that of vaginally delivered infants, and C-section delivery has been associated with increased risk for immune and metabolic disorders. Here we conducted a pilot study in which infants delivered by C-section were exposed to maternal vaginal fluids at birth. Similarly to vaginally delivered babies, the gut, oral and skin bacterial communities of these newborns during the first 30 d of life was enriched in vaginal bacteria--which were underrepresented in unexposed C-section-delivered infants--and the microbiome similarity to those of vaginally delivered infants was greater in oral and skin samples than in anal s

SUBMITTER: Dominguez-Bello MG 

PROVIDER: S-EPMC5062956 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature