Circulating biomarker responses to medical management vs. mechanical circulatory support in severe inotrope-dependent acute heart failure.

ABSTRACT:

Background

Severe inotrope-dependent acute heart failure (AHF) is associated with poor clinical outcomes. There are currently no well-defined blood biomarkers of response to treatment that can guide management or identify recovery in this patient population. In the present study, we characterized the levels of novel and emerging circulating biomarkers of heart failure in patients with AHF over the first 30 days of medical management or mechanical circulatory support (MCS). We hypothesized a shared a plasma proteomic treatment response would be identifiable in both patient groups, representing reversal of the AHF phenotype.

Methods and results

Time course plasma samples of the first 30 days of therapy, obtained from patients managed medically (n = 8) or with implantabl

SUBMITTER: Meredith AJ 

PROVIDER: S-EPMC5063158 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature