Parental smoking and development of allergic sensitization from birth to adolescence.

ABSTRACT:

Background

The relation between secondhand tobacco smoke (SHS) exposure and the development of allergic sensitization in children is unclear. The aim of this study was to determine whether maternal smoking during pregnancy and postnatal SHS exposure contributes to the development of allergic sensitization in children and adolescents up to 16 years of age.

Methods

We included 3316 children from a birth cohort followed up for 16 years. SHS exposure and symptoms of allergic disease were assessed using repeated parental questionnaires. Serum immunoglobulin E against eight common inhalant and six food allergens was assessed at ages 4, 8, and 16 years with ImmunoCAP. The association between SHS exposure and sensitization was explored using logistic regression and generalized estim

SUBMITTER: Thacher JD 

PROVIDER: S-EPMC5063181 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature