Dataset Information

The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group.

ABSTRACT:

Background and purpose

Nonmotor symptoms (NMS) in Parkinson's disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients.

Methods

We surveyed patients in 37 movement-disorders clinics throughout Korea. In total, 323 PD patients were recruited for assessment of disease severity and duration, NMS, HrQoL, and other clinical variables including demographics, cognition, sleep scale, fatigability, and symptoms.

Results

In total, 98.1% of enrolled PD subjects suffered from various kinds of NMS. The prevalence of NMS and scores in each NMS domain were significantly higher in the PD group, and the NMS worsened as the disease progressed. Among clinical variables, disease duration and depressive mood showed significant correlations with all NMS domains (p<0.001). NMS status impacted HrQoL in PD (rS=0.329, p<0.01), and the association patterns differed with the disease stage.

Conclusions

The results of our survey suggest that NMS in PD are not simply isolated symptoms of degenerative disease, but rather exert significant influences throughout the disease course. A novel clinical approach focused on NMS to develop tailored management strategies is warranted to improve the HrQoL in PD patients.

SUBMITTER: Kwon DY

PROVIDER: S-EPMC5063863 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature

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Publications

The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group.

Kwon Do Young DY Koh Seong Beom SB Lee Jae Hyeok JH Park Hee Kyung HK Kim Han Joon HJ Shin Hae Won HW Youn Jinyoung J Park Kun Woo KW Choi Sun Ah SA Kim Sang Jin SJ Choi Seong Min SM Park Ji Yun JY Jeon Beom S BS Kim Ji Young JY Chung Sun Ju SJ Lee Chong Sik CS Park Jeong Ho JH Ahn Tae Beom TB Kim Won Chan WC Kim Hyun Sook HS Cheon Sang Myung SM Kim Hee Tae HT Lee Jee Young JY Kim Ji Sun JS Kim Eun Joo EJ Kim Jong Min JM Lee Kwang Soo KS Kim Joong Seok JS Kim Min Jeong MJ Baik Jong Sam JS Park Ki Jong KJ Kim Hee Jin HJ Park Mee Young MY Kang Ji Hoon JH Song Sook Kun SK Kim Yong Duk YD Yun Ji Young JY Lee Ho Won HW Oh Hyung Geun HG Cho Jinwhan J Song In Uk IU Sohn Young H YH Lee Phil Hyu PH Kim Jae Woo JW

Journal of clinical neurology (Seoul, Korea) 20161001 4

<h4>Background and purpose</h4>Nonmotor symptoms (NMS) in Parkinson's disease (PD) have multisystem origins with heterogeneous manifestations that develop throughout the course of PD. NMS are increasingly recognized as having a significant impact on the health-related quality of life (HrQoL). We aimed to determine the NMS presentation according to PD status, and the associations of NMS with other clinical variables and the HrQoL of Korean PD patients.<h4>Methods</h4>We surveyed patients in 37 mo ...[more]

PMID: 27819413

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Dataset Information

The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group.

Background and purpose

Methods

Results

Conclusions

Publications

The KMDS-NATION Study: Korean Movement Disorders Society Multicenter Assessment of Non-Motor Symptoms and Quality of Life in Parkinson's Disease NATION Study Group.

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