Ontology highlight
ABSTRACT:
SUBMITTER: Kimura T
PROVIDER: S-EPMC5064021 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nature communications 20161012
Macrophages play crucial roles in host defence and tissue homoeostasis, processes in which both environmental stimuli and intracellularly generated metabolites influence activation of macrophages. Activated macrophages are classified into M1 and M2 macrophages. It remains unclear how intracellular nutrition sufficiency, especially for amino acid, influences on macrophage activation. Here we show that a lysosomal adaptor protein Lamtor1, which forms an amino-acid sensing complex with lysosomal va ...[more]