Kojic Acid Peptide: A New Compound with Anti-Tyrosinase Potential.

ABSTRACT:

Background

Kojic acid was used for decades in the cosmetic industry as an antimelanogenic agent. However, there are two major drawbacks of Kojic acid, one is cytotoxicity and second are instability on storage. These limitations led the scientist to synthesize the active Kojic acid peptides.

Objective

In the present study, we synthesize and investigate the effect of five Kojic acid peptides to overcome the limitation of Kojic acid.

Methods

The peptide was analyzed and purified by high-performance liquid chromatography and matrix-assisted laser desorption ionization time of flight mass spectroscopy. Further, the tyrosinase activities of the Kojic acid and Kojic acid peptides were compared. The toxicity was measured and the melanin content is recorded in B16F10 mouse mel

SUBMITTER: Singh BK 

PROVIDER: S-EPMC5064183 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature