Temporal regularity of intrinsic cerebral activity in patients with chronic primary insomnia: a brain entropy study using resting-state fMRI.

ABSTRACT:

Introduction

Several neuroimaging studies have suggested that patients with chronic primary insomnia (CPI) exhibit anatomical and functional alterations of the brain, but the temporal regularity in spontaneous neuronal activity remains unknown. Here, brain entropy (BEN), a data-driven method used to measure the signal regularity of a time series, was applied for the first time to investigate changes in the entire brain at the voxel level.

Methods

Resting-state functional MRI data were used to investigate insomnia-related BEN alterations and the resting-state functional connectivity (rsFC) pattern in seed regions with altered BEN in 29 patients with identified and untreated CPI and 29 matched healthy controls. Subsequently, within the CPI group, correlation analysis was condu

SUBMITTER: Zhou F 

PROVIDER: S-EPMC5064341 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature