Microcurrent stimulation promotes reverse remodelling in cardiomyocytes.

ABSTRACT:

Aims

It has been shown that electrical stimulation can improve tissue repair in patients. Imbalances in the extracellular matrix composition induce manifestation of heart failure. Here we investigated the application of microcurrent (MC) to modulate the expression of matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in cardiomyocytes in vitro and in vivo to reverse remodelling in the heart in spontaneous hypertensive rats (SHR).

Methods

Cardiomyocytes from young SHR (7 months) and old SHR (14 months) were stimulated in vitro and in vivo with MC. MMP and TIMP expression were analysed by qPCR and immunofluorescence to evaluate the modulation of MC treatment.

Results

Modulation of cardiomyocytes with MC enhanc

SUBMITTER: Kapeller B 

PROVIDER: S-EPMC5064659 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature