Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats.

ABSTRACT:

Background

Multi-walled carbon nanotubes (MWCNTs) constitute one of the most promising types of nanomaterials in industry today. With their increasing use, the potential toxicity and carcinogenicity of MWCNT needs to be evaluated in bioassay studies using rodents. Since humans are mainly exposed to MWCNT by inhalation, we performed a 104-week carcinogenicity study using whole-body inhalation exposure chambers with a fibrous straight type of MWCNT at concentrations of 0, 0.02, 0.2, and 2 mg/m³ using male and female F344 rats.

Results

Lung carcinomas, mainly bronchiolo-alveolar carcinoma, and combined carcinomas and adenomas were significantly increased in males exposed to 0.2 and 2 mg/m³ MWNT-7 and in females exposed to 2 mg/m³ MWNT-7 compared

SUBMITTER: Kasai T 

PROVIDER: S-EPMC5064785 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature