Elevated CETP Lipid Transfer Activity is Associated with the Risk of Venous Thromboembolism.

ABSTRACT:

Aim

Cholesteryl ester transfer protein (CETP) is an important lipid transfer factor in plasma that enhances prothrombinase activity in purified systems. This study was conducted to test the association of plasma CETP activity with venous thrombosis (VTE) and to address the procoagulant mechanism of CETP activity in prothrombinase assays.

Methods

We measured CETP lipid transfer activity in plasmas of 49 male VTE patients and in plasmas of matched controls. CETP procoagulant activity was tested in purified prothrombinase systems.

Results

CETP lipid transfer activity levels were significantly higher in VTE patients than in controls (p=0.0008). A subset of patients carrying the CETP mutations Ala373Pro and Arg451Gln, which were also linked to the VTE risk, showed signific

SUBMITTER: Deguchi H 

PROVIDER: S-EPMC5064881 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature