Risk factors, host response and outcome of hypothermic sepsis.

ABSTRACT:

Background

Hypothermia is associated with adverse outcome in patients with sepsis. The objective of this study was to characterize the host immune response in patients with hypothermic sepsis in order to determine if an excessive anti-inflammatory response could explain immunosuppression and adverse outcome. Markers of endothelial activation and integrity were also measured to explore potential alternative mechanisms of hypothermia. Finally we studied risk factors for hypothermia in an attempt to find new clues to the etiology of hypothermia in sepsis.

Methods

Consecutive patients diagnosed with sepsis within 24 hours after admission to ICUs in two tertiary hospitals in the Netherlands were included in the study (n = 525). Hypothermia was defined as body temperature below 36

SUBMITTER: Wiewel MA 

PROVIDER: S-EPMC5064908 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature