A Peculiar Formula of Essential Amino Acids Prevents Rosuvastatin Myopathy in Mice.

ABSTRACT:

Aims

Myopathy, characterized by mitochondrial oxidative stress, occurs in ∼10% of statin-treated patients, and a major risk exists with potent statins such as rosuvastatin (Rvs). We sought to determine whether a peculiar branched-chain amino acid-enriched mixture (BCAAem), found to improve mitochondrial function and reduce oxidative stress in muscle of middle-aged mice, was able to prevent Rvs myopathy.

Results

Dietary supplementation of BCAAem was able to prevent the structural and functional alterations of muscle induced by Rvs in young mice. Rvs-increased plasma 3-methylhistidine (a marker of muscular protein degradation) was prevented by BCAAem. This was obtained without changes of Rvs ability to reduce cholesterol and triglyceride levels in blood. Rather, BCAAem promote

SUBMITTER: D'Antona G 

PROVIDER: S-EPMC5065032 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature