Neural changes in extinction recall following prolonged exposure treatment for PTSD: A longitudinal fMRI study.

ABSTRACT:

Background

Neurobiological models of posttraumatic stress disorder (PTSD) implicate fear processing impairments in the maintenance of the disorder. Specific deficits in extinction recall, the retention of learned extinction, have been demonstrated. While deficient extinction recall, and the associated activation pattern of prefrontal and hippocampal regions, distinguishes individuals with PTSD from controls, research has not yet examined changes following treatment. We examined the behavioral and neural correlates of extinction recall before and after cognitive behavioral treatment of PTSD.

Methods

Fifty-eight participants (30 with PTSD, 28 trauma-exposed matched controls) underwent a 2-day behavioral fear conditioning, extinction, and recall paradigm during functional magne

SUBMITTER: Helpman L 

PROVIDER: S-EPMC5065048 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature