Ontogeny of Unstable Chromosomes Generated by Telomere Error in Budding Yeast.

ABSTRACT: DNA replication errors at certain sites in the genome initiate chromosome instability that ultimately leads to stable genomic rearrangements. Where instability begins is often unclear. And, early instability may form unstable chromosome intermediates whose transient nature also hinders mechanistic understanding. We report here a budding yeast model that reveals the genetic ontogeny of genome rearrangements, from initial replication error to unstable chromosome formation to their resolution. Remarkably, the initial error often arises in or near the telomere, and frequently forms unstable chromosomes. Early unstable chromosomes may then resolve to an internal "collection site" where a dicentric forms and resolves to an isochromosome (other outcomes are possible at each step). The initial tel

SUBMITTER: Beyer T 

PROVIDER: S-EPMC5065131 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature