Jump into a New Fold-A Homology Based Model for the ABCG2/BCRP Multidrug Transporter.

ABSTRACT: ABCG2/BCRP is a membrane protein, involved in xenobiotic and endobiotic transport in key pharmacological barriers and drug metabolizing organs, in the protection of stem cells, and in multidrug resistance of cancer. Pharmacogenetic studies implicated the role of ABCG2 in response to widely used medicines and anticancer agents, as well as in gout. Its Q141K variant exhibits decreased functional expression thus increased drug accumulation and decreased urate secretion. Still, there has been no reliable molecular model available for this protein, as the published structures of other ABC transporters could not be properly fitted to the ABCG2 topology and experimental data. The recently published high resolution structure of a close homologue, the ABCG5-ABCG8 heterodimer, revealed a new ABC tra

SUBMITTER: Laszlo L 

PROVIDER: S-EPMC5065228 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature