Appendectomy does not decrease the risk of future colectomy in UC: results from a large cohort and meta-analysis.

ABSTRACT:

Objectives

Early appendectomy is inversely associated with the development of UC. However, the impact of appendectomy on the clinical course of UC is controversial, generally favouring a milder disease course. We aim to describe the effect appendectomy has on the disease course of UC with focus on the timing of appendectomy in relation to UC diagnosis.

Design

Using the National Institute of Diabetes and Digestive and Kidney Diseases Inflammatory Bowel Disease Genetics Consortium database of patients with UC, the risk of colectomy was compared between patients who did and did not undergo appendectomy. In addition, we performed a meta-analysis of studies that examined the association between appendectomy and colectomy.

Results

2980 patients with UC were initially includ

SUBMITTER: Parian A 

PROVIDER: S-EPMC5065377 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature