Testosterone-dependent sex differences in red blood cell hemolysis in storage, stress, and disease.

ABSTRACT:

Background

Red blood cell (RBC) hemolysis represents an intrinsic mechanism for human vascular disease. Intravascular hemolysis releases hemoglobin and other metabolites that inhibit nitric oxide signaling and drive oxidative and inflammatory stress. Although these pathways are important in disease pathogenesis, genetic and population modifiers of hemolysis, including sex, have not been established.

Study design and methods

We studied sex differences in storage or stress-induced hemolysis in RBC units from the United States and Canada in 22 inbred mouse strains and in patients with sickle cell disease (SCD) using measures of hemolysis in 315 patients who had homozygous SS hemoglobin from the Walk-PHASST cohort. A mouse model also was used to evaluate posttransfusion recovery

SUBMITTER: Kanias T 

PROVIDER: S-EPMC5065383 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature