Lack of association between dopaminergic antagonism and negative symptoms in schizophrenia: a positron emission tomography dopamine D2/3 receptor occupancy study.

ABSTRACT:

Rationale

Several pre-clinical studies suggest that antipsychotic medications cause secondary negative symptoms. However, direct evidence for a relationship among antipsychotic medications, their direct effects on neurotransmitter systems, and negative symptoms in schizophrenia remains controversial.

Objective

The objective of this study was to examine the relationship between antipsychotic-related dopamine D_2/3 receptor occupancy and negative symptoms in patients with schizophrenia.

Methods

Forty-one clinically stable outpatients with schizophrenia participated in this prospective dose reduction positron emission tomography (PET) study. Clinical assessments and [¹¹C]-raclopride PET scans were performed before and after participants underwent gra

SUBMITTER: Fervaha G 

PROVIDER: S-EPMC5065392 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature