Progressive hemorrhagic injury after severe traumatic brain injury: effect of hemoglobin transfusion thresholds.

ABSTRACT: OBJECT There is limited literature available to guide transfusion practices for patients with severe traumatic brain injury (TBI). Recent studies have shown that maintaining a higher hemoglobin threshold after severe TBI offers no clinical benefit. The present study aimed to determine if a higher transfusion threshold was independently associated with an increased risk of progressive hemorrhagic injury (PHI), thereby contributing to higher rates of morbidity and mortality. METHODS The authors performed a secondary analysis of data obtained from a recently performed randomized clinical trial studying the effects of erythropoietin and blood transfusions on neurological recovery after severe TBI. Assigned hemoglobin thresholds (10 g/dl vs 7 g/dl) were maintained with packed red blood cell tra

SUBMITTER: Vedantam A 

PROVIDER: S-EPMC5065393 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature