14-3-3epsilon controls multiple developmental processes in the mouse heart.

ABSTRACT:

Background

14-3-3ε plays an important role in the maturation of the compact ventricular myocardium by modulating the cardiomyocyte cell cycle via p27^kip1 . However, additional cardiac defects are possible given the ubiquitous expression pattern of this protein.

Results

Germ line deletion of 14-3-3ε led to malalignment of both the outflow tract (OFT) and atrioventricular (AV) cushions, with resulting tricuspid stenosis and atresia, mitral valve abnormalities, and perimembranous ventricular septal defects (VSDs). We confirmed myocardial non-compaction and detected a spongy septum with muscular VSDs and blebbing of the epicardium. These defects were associated with abnormal patterning of p27^kip1 expression in the subendocardial and possibly the epicardial

SUBMITTER: Gittenberger-de Groot AC 

PROVIDER: S-EPMC5065397 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature