Increasing Generality and Power of Rare-Variant Tests by Utilizing Extended Pedigrees.

ABSTRACT: Recently, multiple studies have performed whole-exome or whole-genome sequencing to identify groups of rare variants associated with complex traits and diseases. They have primarily utilized case-control study designs that often require thousands of individuals to reach acceptable statistical power. Family-based studies can be more powerful because a rare variant can be enriched in an extended pedigree and segregate with the phenotype. Although many methods have been proposed for using family data to discover rare variants involved in a disease, a majority of them focus on a specific pedigree structure and are designed to analyze either binary or continuously measured outcomes. In this article, we propose RareIBD, a general and powerful approach to identifying rare variants involved in dis

SUBMITTER: Sul JH 

PROVIDER: S-EPMC5065687 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature