Very High-Risk Localized Prostate Cancer: Outcomes Following Definitive Radiation.

ABSTRACT:

Purpose

Existing definitions of high-risk prostate cancer consist of men who experience significant heterogeneity in outcomes. As such, criteria that identify a subpopulation of National Comprehensive Cancer Network (NCCN) high-risk prostate cancer patients who are at very high risk (VHR) for poor survival outcomes following prostatectomy were recently developed at our institution and include the presence of any of the following disease characteristics: multiple NCCN high-risk factors, primary Gleason pattern 5 disease and/or ≥5 biopsy cores with Gleason sums of 8 to 10. Whether these criteria also apply to men undergoing definitive radiation is unclear, as is the optimal treatment regimen in these patients.

Methods and materials

All men consecutively treated with definitive

SUBMITTER: Narang AK 

PROVIDER: S-EPMC5065713 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature