The relatively poor correlation between random and 24-hour urine protein excretion in patients with biopsy-proven glomerular diseases.

ABSTRACT: Random urine protein creatinine ratios are used to estimate 24-hour urine protein excretion, which is considered a diagnostic gold standard. However, few studies are available of the sensitivity and specificity of this estimation in patients with glomerular proteinuria. To clarify this, we measured the urine protein and creatinine centrally in random and 24-hour urine collections at biopsy and longitudinally every 6 months in individuals participating in the Nephrotic Syndrome Study Network (NEPTUNE) cohort with glomerular disease. In the initial developmental cohort, 302 patients had same day random and 24-hour samples with a total of 827 paired measurements across all visits. The protein excretion (g/day) was higher in adult than pediatric patients. The correlation between the random uri

SUBMITTER: Hogan MC 

PROVIDER: S-EPMC5065749 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature