Modulation of Primary Immune Response by Different Vaccine Adjuvants.

ABSTRACT: Adjuvants contribute to enhancing and shaping the vaccine immune response through different modes of action. Here early biomarkers of adjuvanticity after primary immunization were investigated using four different adjuvants combined with the chimeric tuberculosis vaccine antigen H56. C57BL/6 mice were immunized by the subcutaneous route with different vaccine formulations, and the modulation of primary CD4⁺ T cell and B cell responses was assessed within draining lymph nodes, blood, and spleen, 7 and 12 days after priming. Vaccine formulations containing the liposome system CAF01 or a squalene-based oil-in-water emulsion (o/w squalene), but not aluminum hydroxide (alum) or CpG ODN 1826, elicited a significant primary antigen-specific CD4⁺ T cell response compared to a

SUBMITTER: Ciabattini A 

PROVIDER: S-EPMC5066114 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature