Development of a Potent and Selective HDAC8 Inhibitor.

ABSTRACT: A novel, isoform-selective inhibitor of histone deacetylase 8 (HDAC8) has been discovered by the repurposing of a diverse compound collection. Medicinal chemistry optimization led to the identification of a highly potent (0.8 nM) and selective inhibitor of HDAC8.

SUBMITTER: Ingham OJ 

PROVIDER: S-EPMC5066159 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature