Associations between Periodontal Microbiota and Death Rates.

ABSTRACT: It is conceived that specific combinations of periodontal bacteria are associated with risk for the various forms of periodontitis. We hypothesized that such specificity is also related to human cause-specific death rates. We tested this hypothesis in a representative sample of the US population followed for a mean duration of 11 years and found that two specific patterns of 21 serum antibodies against periodontal bacteria were significantly associated with increased all-cause and/or diabetes-related mortalities. These data suggested that specific combinations of periodontal bacteria, even without inducing clinically significant periodontitis, may have a significant impact on human cause-specific death rates. Our findings implied that increased disease and mortality risk could be transmitt

SUBMITTER: Chiu CJ 

PROVIDER: S-EPMC5066247 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature