Arsenic-induced instrumental genes of apoptotic signal amplification in death-survival interplay.

ABSTRACT: Arsenic is a global health concern at present and it is well reported for causing systemic toxicity. It is also well known for generation of free radical and inducing apoptosis in different cell types. Paradoxically arsenic is reported to be a susceptible carcinogen as well. There are several reports demonstrating diverse mechanism of apoptosis in different cell types. However, the universal scenario of instrumental genes and their interaction leading to amplification of apoptotic signal are yet to be completely uncovered, which is predicted here. Conventional studies on signaling pathway aided by time and concentration kinetics data are inadequate for prediction of anchored genes for apoptotic signal amplification. Therefore, expression profile-based approach is adopted. Core apoptosis re

SUBMITTER: Roy S 

PROVIDER: S-EPMC5066266 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature