The NMDA receptor partial agonist d-cycloserine does not enhance motor learning.

ABSTRACT:

Rationale

There has recently been increasing interest in pharmacological manipulations that could potentially enhance exposure-based cognitive behaviour therapy for anxiety disorders. One such medication is the partial NMDA agonist d-cycloserine. It has been suggested that d-cycloserine enhances cognitive behaviour therapy by making learning faster. While animal studies have supported this view of the drug accelerating learning, evidence in human studies has been mixed. We therefore designed an experiment to measure the effects of d-cycloserine on human motor learning.

Methods

Fifty-four healthy human volunteers were randomly assigned to a single dose of 250mg d-cycloserine versus placebo in a double-blind design. They then performed a motor sequence learning task.

Result

SUBMITTER: Gunthner J 

PROVIDER: S-EPMC5066480 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature