Eukaryotic transcription initiation machinery visualized at molecular level.

ABSTRACT: The structures of RNA Polymerase (Pol) II pre-initiation complexes (PIC) have recently been determined at near-atomic resolution, elucidating unprecedented mechanistic details of promoter opening during transcription initiation. The key structural features of promoter opening are summarized here. Structural knowledge of Pol I and III PIC is also briefly discussed.

SUBMITTER: Han Y 

PROVIDER: S-EPMC5066506 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature