Stable Radiolabeling of Sulfur-Functionalized Silica Nanoparticles with Copper-64.

ABSTRACT: Nanoparticles labeled with radiometals enable whole-body nuclear imaging and therapy. Though chelating agents are commonly used to radiolabel biomolecules, nanoparticles offer the advantage of attaching a radiometal directly to the nanoparticle itself without the need of such agents. We previously demonstrated that direct radiolabeling of silica nanoparticles with hard, oxophilic ions, such as the positron emitters zirconium-89 and gallium-68, is remarkably efficient. However, softer radiometals, such as the widely employed copper-64, do not stably bind to the silica matrix and quickly dissociate under physiological conditions. Here, we overcome this limitation through the use of silica nanoparticles functionalized with a soft electron-donating thiol group to allow stable attachment of cop

SUBMITTER: Shaffer TM 

PROVIDER: S-EPMC5066563 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature