Integrated network analysis reveals distinct regulatory roles of transcription factors and microRNAs.

ABSTRACT: Analysis of transcription regulatory networks has revealed many principal features that govern gene expression regulation. MicroRNAs (miRNAs) have emerged as another major class of gene regulators that influence gene expression post-transcriptionally, but there remains a need to assess quantitatively their global roles in gene regulation. Here, we have constructed an integrated gene regulatory network comprised of transcription factors (TFs), miRNAs, and their target genes and analyzed the effect of regulation on target mRNA expression, target protein expression, protein-protein interaction, and disease association. We found that while target genes regulated by the same TFs tend to be co-expressed, co-regulation by miRNAs does not lead to co-expression assessed at either mRNA or protein le

SUBMITTER: Guo Y 

PROVIDER: S-EPMC5066619 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature