Immunotherapy using algal-produced Ara h 1 core domain suppresses peanut allergy in mice.

ABSTRACT: Peanut allergy is an IgE-mediated adverse reaction to a subset of proteins found in peanuts. Immunotherapy aims to desensitize allergic patients through repeated and escalating exposures for several months to years using extracts or flours. The complex mix of proteins and variability between preparations complicates immunotherapy studies. Moreover, peanut immunotherapy is associated with frequent negative side effects and patients are often at risk of allergic reactions once immunotherapy is discontinued. Allergen-specific approaches using recombinant proteins are an attractive alternative because they allow more precise dosing and the opportunity to engineer proteins with improved safety profiles. We tested whether Ara h 1 and Ara h 2, two major peanut allergens, could be produced using c

SUBMITTER: Gregory JA 

PROVIDER: S-EPMC5066676 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature